October 21, 2009

Research Proposal on In vitro fertilization (IVF)

In vitro fertilization (IVF) - referring to innovative procedure involves harvesting the egg and sperm to create an artificial embryo as these embryos can then be injected into the uterus to begin the conception process.

IVF place an innovative reproductive technology that ideally have profound influence on certain therapeutic and diagnostic management of infertility, outcomes for better understanding of human fertilization and embryo development. For example, pregnancy rates in IVF can be in low formation, as in-depth investigation should be directed to improve the implantation rates, and to develop better methods of IVF development. More studies are needed, presenting in potential utilization for IVF process put into a promising trend for research as well as development. IVF have generated serious ethical and legal issues as needed to be developed to protect research participants when regulation is clear, as ethical guidelines and appropriate legislation from medical and scientific community are established worldwide.

Reproductive function have shown to be sensitive to changes, although reproductive effects of exposure to hazardous chemicals have been well documented in literature, there can be evidence for adverse reproductive effects of physical and psychosocial environments. The considering of male and female partners since it is essentially their combined contributions of gametes which lead to successful IVF outcomes. In human in vitro fertilization (IVF) embryos are routinely transferred to the uterus on day 2 and or day 3 of the development. The ability to culture embryos to the blastocyst stage should help to resolve this problem by synchronizing the embryo with the female reproductive tract, and by identifying those embryos with little developmental potential. Recent developments in the field of embryo physiology and metabolism have led to the formulation of new sequential media capable of supporting the development of viable blastocysts in several mammalian species, including the human. Furthermore, the development of suitable non-invasive tests of embryo viability should further increase the overall success of human IVF by the ability to select before transfer those blastocysts most able to establish effective pregnancy.

Some of today's common infertility procedures include ovulation injections, fallopian tube scar removal, hormone therapy and the administration of fertility medication. In vitro fertilization (IVF) has been good option being one of the innovative methods for managing infertility, as it makes use of assisted reproductive technology to increase the chances that a woman will conceive. Centers for Disease Control and Prevention's have highlighted that IVF procedures using embryos derived from patients' own freshly fertilized oocytes, the average number of embryos transferred declined from 3.8 to 3.1 (Jain et al., 2004). However, previous detailed studies from the same data source indicate that the pattern of the relation between embryos transferred and multiple birth risk varies by maternal age (Wright et al., 2005). Although the focus is the success of IVF following exposure to hazardous substances in the workplace, the outcome of any attempt to achieve live birth depends on many factors, principally the union of putatively normal sperm with oocytes. The Medline and PubMed databases linking IVF successes and infertility with occupational exposures to hazardous substances.

The need to discuss the available exposure data in relation to reproductive outcomes and describe relevance to IVF. Infertility has often been defined as failure to achieve pregnancy within 1 year of unprotected intercourse. For instance, delays in time it takes to become pregnant or loss of pregnancy before term have been considered as evidence for sub fertility. Among factors thought to affect human fertility are the physical environment, behavioral and socioeconomic factors as well as environmental contaminants. Physical, behavioral and socioeconomic factors have been reported to have an effect on fertility as research in the area is still immature (Bonde, 1999).

The research focuses on In Vitro Fertilization (IVF) in human lining to the current trends in IVF and to answer the question with several literature support and studies catering to achieving fertility through IVF, how to basically achieve a 100 percent fertility in IVF. The need to understand and identify what IVF is about and to recognize valuable information base in IVF trends that will lead to 100 percent fertility through using and executing IVF technique. The identification as well as discussion of essential elements for successful IVF program is to be a major part of the research paradigm also, linking to the procedural steps in human IVF and assume clinical outcomes of IVF as based on secondary research, comprising in of past empirical research. The noting in of ethical and legal aspects of IVF technology. The core methodology is through utilizing literature studies, organizing in critical appraisal of three to five research articles/journals that outcomes into research critique, the selection of these peer reviewed research will have a strong basis of paper content and context formation and that will be about IVF that implies to the study focus and how the process works along with several theories and concepts.


Bonde JP (1999) Environmental fertility research at the turn of the century. Scand J Work Environ Health 25,529-536

Jain T, Missmer SA and Hornstein MD (2004) Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States. New Engl J Med 350,1639-1645

Wright VC, Schieve LA, Reynolds MA and Jeng G (2005) Assisted reproductive technology surveillance-United States, 2002. In Surveillance Summaries, June 3, 2005 MMWR 54(SS-2),1-19.

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